About ISM
Founded in 1995, ISM - Immune System Management is a Canadian biotechnology company focused on quantitative amino acid analysis, individualized formulation design, and immune system function.
Through the Aminomics Platform, ISM applies decades of experience to support amino acid balance through measured data, proprietary profile mapping, and customized programs.
Built on biochemical individuality.
ISM was founded on the principle that each individual’s biochemical profile is unique. Aminomics reflects this principle by using quantitative blood plasma amino acid profiling to assess individual amino acid patterns and guide customized formulation design.
Rather than relying on generalized protocols, ISM focuses on measured amino acid data and long-term profile management.
The origins of Aminomics.
ISM was founded by William “Bill” O’Neill and Kathryn O’Neill, whose work helped establish the foundation of the Aminomics Platform.
Their early work focused on the relationship between amino acid balance, protein synthesis, biochemical regulation, and immune system function.
What began as a specialized inquiry into individual biochemical patterns became the foundation for ISM’s proprietary approach to quantitative amino acid analysis and customized formulation design.
“Disease is as unique as the individual.”
— William “Bill” O’Neill, Founder of the Aminomics Platform
Decades of applied Aminomics experience.
Since 1995, ISM has applied the Aminomics Platform through individualized programs involving blood plasma amino acid profiling, profile mapping, customized formulations, and reassessment over time.
Many ISM clients have participated in Aminomics programs over many years, giving ISM a uniquely long-term perspective on amino acid balance, formulation design, and immune system management.
A focused, relationship-driven model.
Today, ISM operates through a remote, boutique model built on discretion, long-term relationships, practitioner collaboration, and individualized assessment.
Many clients have participated in Aminomics programs over many years, giving ISM a rare long-term perspective on amino acid balance, profile mapping, and customized formulation design.
This focused model allows ISM to prioritize depth, continuity, and quality over volume.